This panel will describe a real-life example in which a public health approach was applied to reduce the risk of occupational fatalities. Using the example of fatal falls overboard in commercial fishing, presenters will describe how they used surveillance data to define the problem, identified risk and protective factors, developed and implemented data-driven interventions, and then evaluated intervention effectiveness. The presenters will describe their research and lessons learned from this multi-year study in a way that demonstrates a how the public health approach to injury prevention can be successfully applied to other industries and occupational hazards. Presenters will highlight several key findings: the importance of partnerships in successfully conducting epidemiological research and translating research findings into practice; the importance of using data to identify the needs of specific worker groups and inform tailored prevention programs; the value of involving affected workers and employers in the development and testing of interventions; and the need to formally evaluate interventions and activities to measure progress in reducing occupational hazards.