From the largest to the smallest public health jurisdictions, events occur that require the responsible public health authorities to track and rapidly assimilate and interpret the health consequences. Such events vary from those of international dimensions (e.g., earthquakes, hurricanes, tsunamis, and infectious pandemics) and other disasters, including human-made and natural environmental events and foodborne, vector-borne and respiratory outbreaks at local or regional levels. Whatever the extent of a public health problem, epidemiologists are called on by their constituencies to track these phenomenon and interpret new data as they accumulate. Both the optimal response to a health event and public health practitioners’ (often impatient) political authorities and constituencies require rapid assimilation, interpretation, and communication of data. To undergird these activities, we present “Red Sky,” a web-based, real-time data visualization dashboard, already used by CDC programs and leadership to monitor, evaluate, and make informed decisions regarding public health events of national and international scope. Red sky is built on the latest web technologies. It is a fully responsive dynamic dashboard with information pulled from multiple data sources, compiled in near real-time, and presented in innovative and user-friendly ways. Red Sky is extensible/scalable and capable of consuming and outputting new data from sources in close to real time. Moreover, the software can share data in a secure and reliable manner with health partners designated by the primary user. Although born for use in the context of public health emergency operations, this technology can be appropriately scaled for use in a variety of contexts by health officials worldwide. Built-in capabilities can be augmented with other additional functionality suitable for specific users. Red Sky can be integrated easily with other commonly used data analytic (e.g., SAS, R) and geographic (e.g., ESRI) software, although these additional high-priced programs are not required for full Red Sky functionality. In sum, Red Sky allows public health officials worldwide to analyze and make timely decisions regarding health-related events while also supporting effective planning and preparedness during non-emergency, non-epidemic periods.